Granulomatous Uveitis Testing: What is included in bloodwork?

• A. CBC, ESR, CRP, RF, ANA, ACE
• B. HbA1c, lipid panel
• C. TSH, free T4
• D. Vitamin D

Answer: (A)

Granulomatous uveitis often signals a systemic inflammatory or granulomatous condition, so the bloodwork is chosen to screen for those underlying etiologies. A CBC gives a baseline of blood cell counts and can reveal anemia or leukocytosis that accompany chronic inflammation or infection. ESR and CRP are inflammatory markers that help gauge the degree of systemic inflammation you might see with conditions like sarcoidosis or infectious processes. Autoimmune screening with RF and ANA helps uncover connective tissue diseases or autoimmune conditions (such as rheumatoid arthritis or lupus) that can present with uveitis. ACE level is included because it can be elevated in sarcoidosis, a common granulomatous disease associated with ocular involvement, and while not specific, it supports suspicion when interpreted with other findings. The other tests listed are less directly related to evaluating granulomatous uveitis: metabolic screens like HbA1c and lipid panel, thyroid function tests, or vitamin D are not typically part of the standard initial bloodwork for this presentation.