Non-Granulomatous Uveitis Testing: Which list of tests is included?

• A. NaFl only
• B. NaFl, Anterior chamber evaluation, Macular OCT, DFE, Gonio, Bloodwork if bilateral or recurrent (HLAB27, ANA, RF, ESR, CRP, Lyme antibody titer ELISA)
• C. Visual field testing only
• D. Serum glucose and lipid panel

Answer: (B)

Non-granulomatous uveitis requires a thorough ocular assessment plus selective systemic screening because inflammation can involve multiple parts of the eye and may be linked to systemic diseases. Documenting anterior chamber activity with slit-lamp examination establishes current inflammation. Using fluorescein (NaFl) helps perform angiography to uncover retinal vasculitis, leakage, or macular edema that isn’t always visible on exam. Macular OCT is essential to detect macular edema, a common and vision-threatening complication that guides treatment decisions. A dilated fundus exam extends the view to the posterior segment, revealing vitreous inflammation, choroiditis, or vasculitis. Gonioscopy assesses the anterior chamber angle for inflammatory synechiae or angle changes that could affect intraocular pressure. When the uveitis is bilateral or recurrent, systemic bloodwork—including HLA-B27, ANA, RF, ESR, CRP, and Lyme antibody testing—helps identify associated autoimmune or infectious etiologies and tailor systemic therapy. The combination of targeted ocular imaging, anterior chamber assessment, and selective systemic labs provides a comprehensive, clinically useful work-up for this presentation.