Which statement describes a potential side effect of the first-line POAG drop Latanoprost?

• A. Pigment changes in the iris
• B. Lash growth
• C. Hyperemia
• D. All of the above

Answer: (D)

Latanoprost lowers eye pressure by increasing uveoscleral outflow and, as a prostaglandin analog, commonly causes several identifiable side effects. Iris pigment changes occur because prostaglandins can stimulate melanin production in the iris stroma, leading to gradual darkening that is more noticeable in lighter-colored irises and can be permanent. Eyelash growth is a well-documented effect, with longer, thicker lashes due to action on hair follicles. Conjunctival hyperemia results from dilated conjunctival vessels and is usually mild but quite common. Since each of these effects can occur with latanoprost, the statement that all of the above describe potential side effects is the best answer.